Evaluation of Early Therapeutic Effect of Bone Marrow Mesenchymal Stem Cells Transplantation on Injured Spinal Cord in Albino Rats by Two Routes

Background: Stem cells have created hope for treatment of obstinate cases as injured spinal cord (ISC).Objective: aims to assess possible early therapeutic effect bone marrow mesenchymal stem (BM-MSCs) on regeneration ISC and estimate effective transplantation routes in animal models. Material Methods: 62 adult male albino rats were used; two BM-MSCs extraction 60 allocated into three groups. Control group: subjected ISC, intralesional (IL) injected with via injection intravenous (IV) at 3rd day post injury (PCI). Rats examined motor functional recovery. SC specimens extracted histological, morphometric, chemical, Immunological statistical studies. Results: Tracing BM-SCs SC, group versus showed higher number engrafted all studied ages gradual decrease from 1st 6th week PCI. The MSCs counts groups highly significantly increased 1st, weeks but only week. They concentrated site then extended out rostrally caudally. In group, they dispersed over wider area including indicating their capability home. mean cavitation areas treated control significant the smallest observed group. Also highest neurotrophic factors expressions than other increasing pattern decreased Locomotor recovery scores increase improvement Conclusion: This work concluded that gave outstanding improvement. Intravenous route therapy provided locomotor while best histological neuroprotective outcomes.